Laminar Shear Stress Inhibits Endothelial Cell Metabolism via KLF2-Mediated Repression of PFKFB3
نویسندگان
چکیده
منابع مشابه
Laminar shear stress inhibits endothelial cell metabolism via KLF2-mediated repression of PFKFB3.
OBJECTIVE Cellular metabolism was recently shown to regulate endothelial cell phenotype profoundly. Whether the atheroprotective biomechanical stimulus elicited by laminar shear stress modulates endothelial cell metabolism is not known. APPROACH AND RESULTS Here, we show that laminar flow exposure reduced glucose uptake and mitochondrial content in endothelium. Shear stress-mediated reduction...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2015
ISSN: 1079-5642,1524-4636
DOI: 10.1161/atvbaha.114.304277